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Intraosseous Meningioma Associated with Lung Cancer: A case of multiple neoplasms Hisahi KOGA 1 , Jiro MUKAWA 1 , Koichi MIYAGI 1 , Yasunari ISHIKAWA 1 , Mizue SAMURA 1 , Kiyoshi ISHIKAWA 2 , Manabu KUDAKA 2 1Department of Neurosurgery, University of the Ryukyus School of Medicine 2Department of Surgery, Okinawa Hospital, National Sanatorium Keyword: Intraosseous meningioma , Multiple primary neoplasms , Lung cancer pp.539-543
Published Date 1993/6/10
DOI https://doi.org/10.11477/mf.1436900662
  • Abstract
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Intraosseous tumor was found in a 63 year old male patient with lung cancer during metastatic work-up study. Plain skull X-ray film showed a large osteolytic le-sion in the left temporo-parietal bone. Bone and Ga scintigrams revealed an increased activity in this lesion. CT scan demonstrated an isodense lentiform configura-tion, which was homogeneously enhanced with contrast medium. It was iso-intense in T1, and high-intense in T2 and proton weighted MR images. The tumor was re-moved en bloc with surrounding nomal bone. The attached dura was markedly thickened, but there was no tumor infiltration. Histological diagnosis was transitional meningioma with psammoma body. Postoperatively he was transferred back to Okinawa Hospital and right lower lobectomy was performed for the lung tumor. Histological diagnosis was well-dif-ferentiated adenocarcinoma. We examined immunohisto-chemically p53 protein expression, but p53 immunoacti-vity was observed in neither tumor.

Multiple neoplasms associated with brain tumor are relatively rare, but the incidence will increase in the fu-ture as the diagnostic work-up develops. Pathological dia-gnosis will give us the decisive opportunity for proper treatment. It is to be stressed that, in multiple neoplasms, care should be taken to avoid misdiagnosis of metastasis.


Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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