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Effect of Glycerol and Mannitol on the Distribution of Brain Tissue Water Determineol by Differential Calorimetric Scanning Analysis Teruaki KAWANO 1 , Katsutoshi HIRATA 1 , Keisuke TSUTSUMI 1 , Hitoshi MIYAKE 1 , Masaki KURIHARA 1 , Kazuo MORI 1 1Department of Neurosurgery,Nagasaki University School of Medlcine Keyword: Brain edema , Glycerol , Mannitol , Differential scanning carolimetry pp.229-234
Published Date 1992/3/10
DOI https://doi.org/10.11477/mf.1436900411
  • Abstract
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To further clarify their mechanisms as “dehydrators”, the effect of glycerol and mannitol on the distribution of tissue water was studied by using differential scan-ning calorimetry. In normal rat brain, glycerol, 30 mi-nutes after infusion, reduced, by a certain amount, the free water contents. However, mannitol had no effect on the amount of tissue water. In the focal ischemic model, produced by Tamura's method, glycerol reduced the free water contents in the perifocal brain tissue. As for the contralateral brain tissue, mannitol not glycerol, reduced the total water contents.

Above findings suggest that the effect of glycerol is mainly to decrease free water fraction in the non ische-mic brain tissue, while mannitol shows its effect through the decrease it produces in the extra-brain wa-ter fraction.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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