—▼TOPICS—海外での基礎研究と治療開発の動向—基礎研究留学の意義

Global Trends in Pre-clinical Research on Malignant Glioma

Point

・免疫応答と腫瘍周辺環境がグリオーマ分野の主要研究トピックとなっている．

・グリオーマ分野の基礎研究は米国と中国が牽引している．

　Finding novel treatment approaches for brain tumors is challenging, especially for malignant gliomas. A wealth of genetic and expression data on malignant glioma has accumulated in recent years; however, therapies targeting the underlying oncogenic pathways have not succeeded in substantially improving therapeutic responses or survival, owning to tumor resistance mechanisms to these therapies. Therefore, new therapeutic approaches are necessary to reduce the mortality rates in patients with glioma. This study examined current trends in preclinical research for malignant glioma to predict future therapies. This analysis revealed that current preclinical research mainly focused on the immune response and tumor microenvironment. Knowledge from these researches may lead to the development of new therapeutics for the management of malignant glioma.