—▼TOPICS—グリオーマ患者のQOL評価の意義

Significance of Quality of Life Evaluation for Glioma Patients

Point

・多くのがん腫でpatient reported outcome（PRO）, quality of life（QOL）は予後と相関することが示され，グリオーマ診療にかかわる際に今後一定の知識が必要となることが予想される．

・臨床試験でのQOLの解釈には，それぞれの試験で用いられたQOL評価内容や評価法の定義などを整理した上で結果を理解する必要がある．

　Typically, overall and progression-free survival are used as endpoints in clinical tri-als investigating gliomas, while health-related quality of life（HRQOL）plays a key role in cancer research and may be useful for individual patient care. Previous studies have shown that HRQOL parameters can serve as independent prognostic factors for survival in patients with cancer, while recent studies have highlighted the usefulness of HRQOL in information management and decision-making in cancer treatment. However, a few studies have shown differences between patients' and physicians' perceptions of cancer treatment. In the future, physicians will be expected to recog-nize the importance of the QOL evaluation tool, not only in clinical trials, but also in general practice for gliomas, considering the characteristics of patients with brain tu-mors. In this study, we reviewed the methods of major HRQOL evaluation and sum-marized the first clinical trials incorporating QOL in glioma treatment.