Neurological Surgery No Shinkei Geka Volume 44, Issue 12 (December 2016)

A Case of Subacute Combined Degeneration Caused by Vitamin B12 Deficiency in a Cervical Spondylosis Surgery Referral Kunio YOKOYAMA 1 , Masahiro KAWANISHI 1 , Akira SUGIE 1 , Makoto YAMADA 1 , Hidekazu TANAKA 1 , Yutaka ITO 1 , Toshihiko KUROIWA 2 1Department of Neurosurgery, Takeda General Hospital 2Department of Neurosurgery, Osaka Medical College Keyword: cervical spondylotic myelopathy , vitamin B12 deficiency , subacute combined degeneration pp.1059-1063
Published Date 2016/12/10
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 A 62-year-old man with a 1-year history of numbness of the extremities, clumsiness, and gait disorder was diagnosed with cervical spondylotic myelopathy at a neighboring clinic and referred to our institution for surgery. The patient had undergone a total gastrectomy 6 years previously. Flattening of the cervical cord, associated with diffuse cervical spondylosis and intramedullary intensity change, was observed on magnetic resonance imaging of the cervical spine. Neurological examination revealed decreased vibratory and position sense in all limbs, with posterior funiculus-based neurological symptoms. Blood biochemistry revealed decreased vitamin B12(VB12)levels and megaloblastic anemia. On the basis of these findings, the patient was diagnosed with subacute combined degeneration(SCD). The patient was treated with VB12 for 3 months;the gait disorder resolved and the intramedullary intensity changes in the posterior column of the medulla oblongata, thoracicus, and spinal cord were no longer observed. SCD is a pathological condition in which recovery of neurological function may be achieved through early administration of VB12. In some cases, it is difficult to differentiate between this condition and cervical spondylotic myelopathy because both diseases exhibit progressive spinal symptoms. The medical history and results of neurological evaluations of the patient are important for an accurate diagnosis, and should therefore not be overlooked.

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Neurological Surgery 脳神経外科
44巻12号 (2016年12月)
電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院