Neurological complications of vitamin deficiency Shigeo MURAYAMA 1 1Geriatric Neuroscience (Neuropathology) Research Group Leader, Tokyo Metropolitan Institute of Gerontology Keyword: beriberi , Wernicke's encephalopathy , subacute combined degeneration , isolated Vitamin E deficiency pp.869-874
Published Date 2002/12/10
DOI https://doi.org/10.11477/mf.1431901438
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The essence of neurological complications of vitamin deficiency is described. Vitamin B1 deficiency causes beriberi and Wernicke encephalopathy. Both present with acute symptoms and are potentially lethal. Beriberi, the first-recognized vitamin deficiency in man, causes peripheral neuropathy, high-output heart failure and lactic acidosis. Neuropathology consists of acute loss of dorsal root ganglion cells and Wallerian degeneration of the large myelinated sensory nerves. Wernicke encephalopathy clinically presents with disturbance in consciousness and eye movement.

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