Treatable Dementia due to Vitamin B12 and Folate Deficiency Toshihiro Yoshizawa 1 1Department of Neurology, NTT Medical Center Tokyo Keyword: ビタミンB12 , 葉酸 , 亜急性連合性変性症 , メチルマロン酸 , ホモシステイン , vitamin B12 , folate , subacute combined degeneration , methylmalonic acid , homocysteine pp.407-420
Published Date 2016/4/1
DOI https://doi.org/10.11477/mf.1416200414
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Vitamin deficiency is one of the major causes of treatable dementia. Specifically, patients suffering from dementia frequentry display low serum levels of vitamin B12. There is a close metabolic interaction between folate and vitamin B12. Folate deficiency causes various neuropsychiatric symptoms, which resemble those observed in vitamin B12 deficiency. This review summarizes, the basic pathophysiology of vitamin B12 and folate deficiency, its clinical diagnosis, associated neuropsychiatric symptoms such as subacute combined degeneration and dementia, and epidemiological studies of cognitive decline and brain atrophy.

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