悪性神経膠腫におけるGFAP染色性とその臨床病態

Clinicopathological Study on Malignant Glioma: With special reference to GFAP

I．はじめに

　glial fibrillary acidic protein（GFAP）はastrogliaに特有のglia filamentの主要成分といわれ，astrocytomaの腫瘍分化度とGFAPの染色性はよく対応するとの諸家の報告がある．

　今回，著者らは，組織学的悪性度およびGFAP染色性と臨床像との相関を検索したので報告する．

In surgical specimens of 91 cases of malignant glial tumor, the correlation between the clinical malignancy of the tumors and the presence of GFA protein in the surgical specimen was examined.

In anaplastic astrocytomas, 20 of 27 cases revealed positive staining of GFAP.

In the cases of glioblastoma multiforme 27 of 35 cases showed GFAP positive staining.

On the other hand, in medulloblatomas, all 29 cases were negative.

In anaplastic astrocytomas and glioblastoma multi-formes, the difference between the survival curves of GFAP positive groups and negative groups were examined.