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A Review of Cell Kinetic Studies on Brain Tumors with a Special Reference to Anti-Bromodeoxyuridine Monoclonal Antibody Method Tadashi NAGASHIMA 1 , Takao HOSHINO 1 1Department of Neurosurgery, University of California, San Francisco Keyword: Cell kinetics , Brain tumor , Glioma , Bromodeoxyuridine , Monoclonal antibody , Flow cytometry pp.1007-1018
Published Date 1984/8/10
DOI https://doi.org/10.11477/mf.1436201893
  • Abstract
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Cell kinetic studies on various human brain tumors were reviewed. Most studies have been carried out by means of 3H-thymidine and autoradiography in the past two decades. The average labeling index (LI) obtained from a pulse of 3H-thymidine is very high in medulloblastomas and glioblastoma multiforme (5-15%), low in well-differentiated gliomas (less than 1%), and intermediate in anaplastic astrocytomas. The higher the LI, the faster the tumor grows, pro-bably reflecting a larger growth fraction.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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