破裂脳動脈瘤患者の血中カテコールアミン値の変動と予後について

A Study on Changes of Plasma Catecholamines Concentrations and Clinical Prognosis in Patients with Ruptured Intracranial Aneurysms

I．はじめに

　血中カテコールアミン（CA）は中枢を介する全身のストレス反応の代謝動態を反映するとされており^2,5,17），近時，特に脳卒中患者の種々の病態における生理活性アミンの変動が注目されている．筆者らは，今回破裂脳動脈瘤患者のCAの経時的変化を追求し，これらの患者の病態と予後との相関性について興味ある知見を得たので報告する．

The plasma catecholamine concentrations have gen-erally been accepted as an index of sympathetic ner-vous activity in cardiovascular and neurologic dis-orders. Intracranial vessels are innervated by sympa-thetic nerve fibers. It is known that the plasmanorepinephrine (NE) level is related to the sympa-thetic activity. Consequently, it is expected that thechanges in sympathetic nervous function are accom-panied by the release of NE at the sympathetic nerveterminals.