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Clinical Efficacy and Cost Benefit of Oral Antimicrobial Prophylaxis with Levofloxacin on Neurological Surgery Yasuhiko AKIYAMA 1 , Takeshi MIYAZAKI 1 , Mitsuhiro DAISU 1 , Yoshiaki YAMAMOTO 1 , Takashi SHINGUU 1 , Nobuyuki MARUYAMA 1 , Hidemasa NAGAI 1 , Kouzo MORITAKE 1 1Department of Neurosurgery,Shimane University School of Medicine Keyword: antimicrobial prophylaxis , oral antibiotics , postsurgical infection , surgical site infection , neurological surgery pp.705-712
Published Date 2006/7/1
DOI https://doi.org/10.11477/mf.1436100254
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 Objective The clinical efficacy and cost benefit of oral antimicrobial prophylaxis with levofloxacin (LVFX) on neurosurgical operation were evaluated.

 Patients and methods Fifty patients undergone burr hole drainage for chronic subdural hematoma were enrolled into this study. These patients had preoperative intravenous drip infusion of 1.0 g of cefazolin (CEZ),and were given oral 200mg of LVFX twice a day for postoperative 6 days on their operations. Clinical effect on prophylaxis of postsurgical infection and surgical site infection as well as safeness of the drug were assessed. Their clinical course were retrospectively compared with another fifty patients as control group who had intravenous administration of CEZ for consecutive 7 days on same operation.

 Results There were no patients who had postsurgical infection and surgical site infection as well as drug related adverse effect,whereas three patients in control group suffered urinary infections or respiratory tract infection during their postsurgical course.

 Conclusions Less invasive oral antimicrobial prophylaxis with LVFX is effective to prevent postoperative infections and surgical site infections,and attractive from the medical economic point of view.


Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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