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Biochemical aspects of circadian rhythms Michio Toru 1 1Division of Psychobiology, National Center for Nervous, Mental and Muscular Disorders pp.1007-1020
Published Date 1981/10/10
DOI https://doi.org/10.11477/mf.1431905330
  • Abstract
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 This paper describes the presence of the circadian rhythm of tryptophan hydroxylase activity in rat pineal gland, together with the physiological and pharmacological properties of the rhythm. An increase in the activity of pineal tryptophan hydroxylase occurred during the first 3 hours of dark period and continued until the lights went on.

 The daily rhythmic fluctuation in pineal tryptophan hydroxylase activity persisted in rats placed under total darkness. 1-Propranolol injection blocked the dark period increase in the activity at 10 p.m. Cycloheximide remarkably decreased the activity.


Copyright © 1981, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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