脱髄性疾患における血清蛋白分劃，血清lipoprotein並に髄液蛋白分劃に関する臨床的並に実験的研究

A Clinical and Experimental Study on Protein and Lipoprotein of Blood Serum and Cerebrospinal Fluid in Demyelinating Diseases

1．緒言

　多発性硬化症は欧米に於ては神経疾患の約10％を占める重要な疾患とされ，その研究も数多い。

　本症に於ける血清蛋白分劃像に関しても，数多くの報告があり，就中Volk^1）等の研究は詳細である。氏等は43例の本症について統計的に検討した結果，その77％にα₂globulin，或はβ-globulinの増加を認めており，γ-globulinは正常値を示すと報告している。

　This report is the results of an investigation ofserum lipoprotein, and protein in serum and cerebrospinal fluid on multiple sclerosis, retrobulbar neuritis, and experimental allergic encephalomyelitis.

　The ratio of β-lipoprotein to α-lipoprotein showed a significant increaes during the period ofexacerbation in multiple sclerosis, retrobulbarneuritis and experimental allergic encephalomyelitis.

　Concerning the protein patterns of the cerebrospinal fluid in multiple sclerosis, two typesof change were observed; one was the increaseboth in β-and γ-globulin fractions and the otherwas the increase only in β-globulin fraction. All patients with retrobulbar neuritis showedthe increase of β-globulin fraction in the cerebrospinal fluid in both stages, remaining γ-globulin fraction normal.

　In the acute stage of experimental allergicencephalomyelitis, β-globulin in cerebrospinalfluid increased but γ-globulin was normal. Inthe period of remission, increase of both β-and γ-globulin was observed.