Clinical features and pathophysiology of narcolepsy; involvement of hypocretin (orexin) systems Mutsumi OKURA 1,2 , Nobuhiro FUJIKI 1 , Mariko OZU 1 , Takashi KANBAYASHI 1,3 , Kazuki HONDA 1,4 , Seiji NISHINO 1 1Center for Narcolepsy, School of Medicine, Stanford University 2Department of Neurology, Kobe City General Hospital 3Department of Psychiatry, Akita University School of Medicine 4Department of Biocybernetics, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University Keyword: ナルコレプシー , モノアミン , コリン , ドーパミン , ヒポクレチン , オレキシン pp.131-160
Published Date 2001/2/10
DOI https://doi.org/10.11477/mf.1431901234
  • Abstract
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Narcolepsy is a disabling sleep disorder characterized by excessive daytime somnolence (EDS), cataplexy and REM sleep-related abnormalities. It is a frequently-occurring but under-diagnosed disorder that affects 0.03 to 0.16% of the general population in various countries. Although most cases occur sporadically, familial clustering may be observed. The disease is tightly associated with the specific Human Leukocyte Antigen (HLA) allele, DQB1 * 0602/DQA1 * 0102 [most often in combination with HLA-DR2 (DRB1 * 15) ].

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