Perspective of α-synuclein and Familial Parkinson's Disease Kenya Nishioka 1 , Nobutaka Hattori 1 1Department of Neurology, Juntendo University School of Medicine Keyword: 家族性パーキンソン病 , αシヌクレイン , 遺伝子 , レヴィ小体 , 総説 , familial Parkinson's disease , α-synuclein , gene , Lewy bodies , review pp.119-129
Published Date 2020/2/1
DOI https://doi.org/10.11477/mf.1416201491
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To date, there have been several reports about the genes associated with familial Parkinson's disease. These genes are classified following the PARK nomenclature. The prevalence of these genes varies between countries. Moreover, each gene is associated with different symptoms during disease progression. In this review, we will summarize the clinical findings and molecular functions, with a focus on alpha-synuclein, along with recent discoveries and will try to associate them with sporadic Parkinson's disease.

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