Mutation of a single gene, klotho leads to aging related disorders. Yoichi NABESHIMA 1 1Cellular Interaction & Morphogenesis, Institute for Mollecular and Cellular Biology, Osaka University Keyword: Klotho遺伝子 , 個体老化 , β-glucosidase pp.764-772
Published Date 1998/10/10
DOI https://doi.org/10.11477/mf.1431900888
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We recently developed a novel unique transgenic mouse with multiple age-related disorders caused by an insertion mutation. The mice homozygous for the transgene show various phenotypes resembling those found in patients with premature aging syndromes; short life span, arteriosclerosis, osteoporosis, impaired oocyte maturation and spermatogenesis, soft tissue calcification, atrophy of thymus, pulmonary emphysema, degeneration of Purkinje cells, and skin atrophy. However, the mice did not show any abnormality in development. We named this mutant klotho for one of the Fates, the Greek goddess who spins the thread of life.

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