Molecular bases of the functional diversity of K+ channels Yoshihiro KUBO 1 1Department of Neurophysiology, Tokyo Metropolitan Institute for Neuroscience Keyword: ポタシウムチャネル , cDNAクローニング , 多様性 , 構造機能連関 pp.211-223
Published Date 1998/4/10
DOI https://doi.org/10.11477/mf.1431900838
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K+ channels are well-known to show highly divergent functional properties. Recent progresses of the molecular biological approaches revealed the molecular bases of the diversity. K+ channels consist of four major families. (1) Voltage-gated K+ channels (Kv) have six transmembrane regions and one pore forming region, and a functional channel is formed by tetrameric multimerization. (2) Inward rectifying K+ channels (Kir) have two transmembrane regions and one pore forming region. A functional channel is also thought to be formed as a tetramer.

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