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Regulation of myelin protein gene expression. Jun ARUGA 1 , Kazuhiro IKENAKA 2 , Chiyo SHIODA 3 , Katsuhiko MIKOSHIBA 1,2 1Division of Chemistry, The Institute of Medical Science, University of Tokyo 2Division of Regulation of Macromolecular Functions, Institute for Protein Research, Osaka University 3Department of Pathology, Wakayama Medical College pp.14-26
Published Date 1992/2/10
DOI https://doi.org/10.11477/mf.1431900208
  • Abstract
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Myelin is an important structure for facilitating the conduction of nerve impulses along the axons both in the central nervous system (CNS) and peripheral rervous system (PNS). In the CNS, oligo-dendrocytes send out processes to recognize the nearby axons and wrap them forming compact lamellae. Myelin basic protein (MBP) and myelin proteolipid protein (PLP) are specifically expressed in oligodendrocyte. Therefore, the studies on the regulation of MBP and PLP gene expression would be expected to yield much information on the molecular mechanism of oligodendrocyte differentiation, as well as the system of gene expression in the nervous system. Moreover, defect in expression of these proteins, results in abnormal myelin lamellae formation causing abnormal behavior such as intentional tremor. Myelin is a convenient model for correlating the changes in molecules with behavior and morphology.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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