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Gene targeting using the mouse embryonic stem cell line. Norio NAKATSUJI 1 , Shigeru NOGUCHI 1 , Hirofumi SUEMORI 1 1Division of Developmental Biology, Meiji Institute of Health Science pp.26-34
Published Date 1991/2/10
DOI https://doi.org/10.11477/mf.1431900107
  • Abstract
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Mouse embryonic stem (ES) cells are pluripotent cell lines established from the inner cell mass (ICM) of blastocysts. They can be maintained in culture as undifferentiated cells with potency to differentiate into various types of tissue cells including germ cells in chimaeric embryos and mice when injected into host blastocysts. Such combination of unlimited proliferation potency in vitro and pluripotency of differentiation in chimaeric animals makes the ES cells a unique important tool of not only the analysis of embryogenesis but also the introduction of new genetic characteristics into the mouse germ line.


Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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