Genomic comparison of human and other primates Naruya Saitou 1 1Division of Population Genetics, National Institute of Genetics Keyword: ヒトゲノム , 分子進化 , 系統樹 , アミノ酸変化 pp.683-691
Published Date 2006/10/10
DOI https://doi.org/10.11477/mf.1431100389
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 New definifition of genome from structural point of view, i.e., largest unit of nucleotides in one self-replicating system, is first introduced. Then human's place in nature was briefly explained,starting from origin of life. Superfamily Hominoidea including human and apes was particularily discussed in detail. After these introductions, our recent studies were mainly reviewed on human and ape genome comparisons. One was analysis of 103 protein coding genes, and 0.56% of human specific amino acid changes were estimated. From this estimate, approximately 80,000 amino acid substitutions were supposed to occur in human lineage after separation from common ancestor of human and chimpanzee. Evolution of FOXP2 gene, first“language”gene, was also discussed. Lastly, importance of chimpanzee genome sequencing studies so as to compare them with human genomes were mentioned, while stressing necessity of simultaneous comparison of other ape genomic sequences.

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