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Treatment of brain tumors using replication-conditional virus and stem cells Takahito Yazaki 1 , Takeshi Kawase 1 1Department of Neurosurgery, School of Medicine, Keio University Keyword: 神経幹細胞 , ウイルス療法 , HSV , TIMP2 , 免疫 pp.931-935
Published Date 2003/12/10
DOI https://doi.org/10.11477/mf.1431100381
  • Abstract
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 Replication-defective vectors for gene therapy of malignant brain tumors have a weak point on transfective efficiency and immune response, and clinical trials using them have not been effective so far. Replication-conditional, oncolytic virus have been developed for overcoming the low efficiency for treating the tumors. Neural stem cells are potentiative candidate for regenerative medicine because of their multipotential on the differentiation. We introduce the experimental trial using these materials for the treatment of brain tumors as novel strategy.


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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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