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Discrimination and learning of complex sounds in the auditory cortex Masaharu Kudoh 1 1Department of Neurophysiology, Brain Research Institute, Niigata University Keyword: 聴覚野 , 音声弁別 , 音順序弁別 , 聴覚学習 , 可塑性 pp.222-233
Published Date 2004/4/10
DOI https://doi.org/10.11477/mf.1431100196
  • Abstract
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 We investigated functions of the auditory cortex(AC)with various approaches:recordings of neuronal responses to complex sounds, experiments of neuronal plasticity in brain slice preparations, and behavioral studies. About half of AC neurons in cats were poorly selective neurons that respond to amplitude modulated tones or bands of noise, while about 10%of neurons were highly selective detectors that respond exclusively to cat voices. Responses of many neurons were correlated with spectrum patterns of stimulus sounds. Long-term potentiation in the AC of adult rats was twice as large as that in the visual cortex. Marked LTP in the AC was attributed to well developed horizontal axon collaterals of supragranular pyramidal neurons in the AC. Discrimination learning of sound order by rats was dependent on cholinergic inputs to the AC. Synaptic potentiation in the supragranular layers following heterosynaptic stimulation was dependent on stimulus sequence in the AC. The sequence dependent synaptic potentiation was dependent on muscarinic receptors, suggesting that it is a part of mechanisms underlying discrimination learning of sound order. Neuronal plasticity may play critical roles in discrimination and learning of sounds with complex spectrum and time patterns in the AC of adult animals.

(Received:January 27, 2004)


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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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