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The molecular biology of Alzheimer's disease Hiroshi MORI 1 1Department of Molecular Biology, Tokyo Institute of Psychiatry Keyword: アルツハイマー病 , 原因遺伝子 , アミロイド , 老人斑 pp.859-865
Published Date 1997/12/10
DOI https://doi.org/10.11477/mf.1431901003
  • Abstract
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Alzheimer's disease (AD) is the most common cause of progressive intellectual failure in aged people. In addition to APP localized on human chromosome 21, the major causal gene of early-onset familial AD was identified as presenilin 1 (PS-1) localized on 14q24.3. The final identification of PS-1 as the causal gene for Alzheimer's disease was concluded based on finding of the point mutations in the candidate cDNA linked with pedigrees with early-onset familial AD. PS-1 is predicted to encode a 467 amino acid protein from the deduced ORF of the cDNA.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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