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Coniin, in Five Little Pigs Kuniyoshi L. Sakai 1 1Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo Keyword: コニイン , ドクニンジン , 毒性アルカロイド , coniine , spotted hemlock , poisonous alkaloid pp.1319-1323
Published Date 2023/12/1
DOI https://doi.org/10.11477/mf.1416202531
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Abstract

In this manuscript, I provide some insights into the novel Five Little Pigs (US title: Murder in Retrospect) by Agatha Christie, and overview the neurotoxin coniine that plays an essential role in that story. Coniine is a nicotinic acetylcholine receptor antagonist, and induces a slowly spreading effect of paralysis by acting directly on the peripheral nervous system. This agent has been used as a poison for thousands of years; indeed, the philosophical text Phaedo describes that coniine was used to put Socrates to death. Based on this background, Christie's views on human nature and her creative powers are also discussed.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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