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Psychiatric Symptoms of Patients With Epilepsy: Characteristics of Psychiatric Adverse Events by Novel Antiepileptic Medications Kosuke Kanemoto 1 , Takuji Nishida 2 , Naoya Hasegawa 3 1Department of Neuropsychiatry, Aichi Medical University 2National Epilepsy Center, NHO Shizuoka Institute of Epilepsy and Neurological Disorders 3Department of Psychiatry, National Hospital Organization, Nishiniigata Chuo Hospital Epilepsy Center Keyword: 抗てんかん発作薬 , 精神症状 , ペランパネル , レベチラセタム , トピラマート , antiseizure medication , psychiatric symptoms , perampanel , levetiracetam , topiramate pp.375-389
Published Date 2023/4/1
DOI https://doi.org/10.11477/mf.1416202343
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Abstract

Patients with epilepsy often show treatment-related psychiatric symptoms. Among the novel antiseizure medications (ASM), Perampanel (PER), Levetiracetam (LEV), and Topiramate (TPM) have been reported to have a relatively high frequency of psychiatric adverse events. However, these psychiatric symptoms are not identical; PER and LEV show adverse events of irritability and aggression, while TPM shows typical symptoms of depression and schizophrenia. It is important to understand the characteristics of these psychiatric adverse events to design appropriate treatment regimens for epileptic patients.

(Received August 1, 2022; Accepted December 24, 2022; Published April 1, 2023)


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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