BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 67, Issue 6 (June 2015)

Adjunctive Therapy with Levetiracetam for Elderly Japanese with Partial Epilepsy: Effectiveness of Levetiracetam in Seizure Management of Epilepsy Patients with Advanced-age Onset in a Practical Setting Toshio Yamauchi 1 , Kosuke Kanemoto 2 , Kensuke Kawai 3 , Shigenobu Ishida 4 , Mayumi Yamada 5 , Takaki Tokumasu 6 , Hirokazu Shirai 6 , Kayo Yamamura 7 1Saitama Medical University 2Department of Neuropsychiatry, Aichi Medical University 3Department of Neurosurgery, NTT Medical Center Tokyo 4Akeno Medical Clinic 5Medical Science Dept., Neurology, UCB Japan Co. Ltd. 6PV, Patient Safety & Quality Assurance Div., UCB Japan Co., Ltd. 7Office of Surveillance Management, Phrmacovegirance Dept. Otsuka Pharmaceutical Co., Ltd. Keyword: レベチラセタム , 抗てんかん薬 , 部分てんかん , 併用療法 , 高齢者 , levetiracetam , antiepileptic drug , partial seizure , adjunctive therapy , elderly pp.749-758
Published Date 2015/6/1
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This prospective, nationwide, specified drug use-results survey investigated the effects of levetiracetam (LEV) in elderly individuals with partial-onset seizures of advanced-age onset in a practical setting. Participants comprised LEV-naïve patients with onset of focal epilepsy at ≥50 years old and management by at least one antiepileptic drug. Efficacy measures were the physician-rated global improvement scale (GIS), and proportions of patients showing 50% and 100% seizure reduction by comparing seizure frequency during the 4-week pre-treatment period and the last 4 weeks of the 25-week treatment period. Adverse drug reactions (ADRs) and retention rate were also evaluated. Data for safety, GIS evaluation, and seizure frequency analyses were available from 105, 78, and 76, respectively, of 116 enrolled patients, 83 (71.55%) of whom were enrolled by neurosurgeons. Improvement rate (improved or markedly improved) as determined by GIS was 98.72% (77/78). Seventy-four (97.37%) and 64 patients (84.21%) showed 50% and 100% seizure reduction, respectively. Incidence of ADRs was 12.38%, including one serious ADR (mania). LEV retention rate remained high at the end of the 25-week treatment period (96.00%). LEV appears efficacious and well-tolerated in elderly patients with focal epilepsy. Including LEV in the treatment regimen may allow elderly patients to achieve freedom from seizures.

(Received November 21, 2014; Accepted January 29, 2015; Published June 1, 2015)

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BRAIN and NERVE-神経研究の進歩
67巻6号 (2015年6月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院