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Efficacy and Safety of Levetiracetam as an Add-on Therapy for Symptomatic Refractory Epilepsy Treated in a Department of Neurosurgery Keiko Suzuki 1 , Tomoyuki Kawataki 1 , Hiroki Sato 1 , Masakazu Ogiwara 1 , Hiroyuki Kinouchi 1 1Department of Neurosurgery, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi Keyword: レベチラセタム , 脳神経外科領域 , 生活の質(QOL) , 併用療法 , levetiracetam , neurosurgery , quality of life , add-on therapy pp.1471-1476
Published Date 2016/12/1
DOI https://doi.org/10.11477/mf.1416200618
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Abstract

The number of patients who suffer from symptomatic partial epilepsy is significant, and those who undergo neurosurgery often experience refractory seizures. Levetiracetam (LEV) is a new-generation anti epileptic drug (AED). Previous studies have shown that LEV has favorable efficacy and a good safety profile with few drug interactions, as it has a unique pharmacological mechanism and acts on synaptic vesicle protein. This study aimed at estimate the efficacy and safety of 1,000 to 2,000 mg/day of LEV as an add-on therapy for refractory symptomatic seizures treated in the department of neurosurgery of our hospital. Twelve patients with >1 seizure attack per year who were administrated one to three AED(s) and had never used LEV were enrolled in this study. The follow-up period was at least 6 months. Seizure-free ratio, health-related quality of life (QOL), and tolerability were assessed. Fifty-eight percent (7/12) of patients were seizure-free, and their “overall QOL”, “energy/fatigue” and “health status” distress-item scores in the QOLIE-31-P had improved. All patients were able to continue oral treatment with LEV without major side effects. Thus, the efficacy and safety of oral add-on LEV therapy were high for these patients.

(Received January 19, 2016; Accepted September 2, 2016; Published December 1, 2016)


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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