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Japanese

Optimal Use of Perampanel in the Treatment of Patients with Epilepsy Based on the Clinical Evidence and Characteristics Naoki Akamatsu 1 , Kousuke Kanemoto 2 , Taketoshi Maehara 3 1Department of Neurology, International University of Health and Welfare School of Medicine 2Department of Neuropsychiatry, Aichi Medical University 3Department of Neurosurgery, Tokyo Medical and Dental University Keyword: ペランパネル , てんかん , 焦点発作 , 全般強直間代発作 , broad spectrum , perampanel , epilepsy , focal seizures , generalized tonic-clonic seizures pp.927-937
Published Date 2022/7/1
DOI https://doi.org/10.11477/mf.1416202151
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Abstract

Perampanel (PER) has been used clinically as monotherapy and adjunctive therapy for focal seizures and as adjunctive therapy for generalized tonic-clonic seizures in epilepsy patients in Japan. In recent years in Japan and worldwide, clinical studies have been conducted on patients with various seizure types of epilepsy. The results have shown that PER has broad spectrum properties. The pooled analysis of controlled trials (PERMIT study) showed PER efficacy in patients with status epilepticus, myoclonic seizures, and absence seizures. In addition, PER has been shown to be safe and effective in patients with juvenile myoclonic epilepsy, Lennox-Gastaut syndrome, and elderly-onset epilepsy that are often difficult to treat with narrow-spectrum ASM. In this review article, we summarize the latest findings on PER, and overview the broad spectrum characteristics of PER. In addition, we discuss the optimal use of PER for patients with epilepsy, focusing on low-dose initiation and on slow titration of PER to minimize adverse events.

(Received December 7, 2021; Accepted March 29, 2022; Published July 1, 2022)


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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