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Mechanisms Underlying Thermosensation Makoto Tominaga 1 , Makiko Kashio 2 1Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences 2Thermal Biology Group, Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences Keyword: 温度 , 温度感受性TRPチャネル , 感覚神経 , 皮膚 , , temperature , thermosensitive TRP channels , sensory neuron , skin , brain pp.127-132
Published Date 2022/2/1
DOI https://doi.org/10.11477/mf.1416201997
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Abstract

The ability to sense ambient temperatures is essential for human survival. Sensory nerve endings contain ion channels that are activated by temperature stimuli, which lead to cation influx and depolarization with consequent action potential generation via activation of voltage-gated Na channels. Thermosensitive transient receptor potential channels play a key role in cation channels. In addition to sensory neurons, the skin is known to detect ambient temperatures. Furthermore, hypothalamic neurons directly detect brain temperature.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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