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Multiple Sclerosis and Gut Microbiome: Current Research and Perspective Takashi Yamamura 1 1Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry Keyword: 多発性硬化症 , 腸内細菌叢 , 短鎖脂肪酸 , 全メタゲノム解析 , 実験的自己免疫性脳脊髄炎 , multiple sclerosis , gut microbiome , short chain fatty acids , whole metagenome analysis , experimental autoimmune encephalomyelitis pp.899-903
Published Date 2021/8/1
DOI https://doi.org/10.11477/mf.1416201857
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Abstract

Multiple sclerosis (MS) is a neurological disease in which alterations of the gut microbiota can be confirmed by metagenomic analysis. In addition to the 16S rRNA analysis, whole metagenomic analysis, as well as, metabolomic analysis, has been applied in this field, which convincingly proved that the reduction of short chain fatty acids characterizes the intestinal environment of patients with MS. Further research is needed to elucidate the mechanisms responsible for the alterations of the gut microbiome in patients with MS. Characterization of the virome may shed light on.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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