Japanese

α-Synuclein as Diagnostic Biomarker Kenjiro Ono 1 1Division of Neurology, Department of Medicine, Showa University School of Medicine Keyword: αシヌクレイン , αシヌクレイノパチー , オリゴマー , バイオマーカー , α-synuclein , α-synucleinopathy , oligomer , biomarker pp.137-141
Published Date 2020/2/1
DOI https://doi.org/10.11477/mf.1416201493
  • Abstract
  • Look Inside
  • Reference

Abstract

Although α-synuclein protein (αS) undergoes aggregation from a monomer to assemblies, such as oligomers, protofibrils, and mature fibrils, the early intermediate aggregates, that is, oligomers, are considered to be the most toxic species in the pathogenesis of α-synucleinopathies, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). While it has been reported that the αS concentration in cerebrospinal fluid (CSF) is decreased significantly in patients with PD and DLB, there have been reports of the αS oligomer concentration being elevated in the CSF of patients with PD. Moreover, it is supposed that the αS oligomer concentration is also elevated in the blood of patients with PD. Recently, it has been reported that lower cerebrospinal β-amyloid (Aβ)1-40, Aβ1-42, and αS levels are associated with cognitive decline in PD. Further combination studies of the CSF and blood may lead to the establishment of the candidate αS as a biomarker for α-synucleinopathies, including PD and DLB.


Copyright © 2020, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

関連文献

もっと見る

文献を共有