Diagnosis of Multiple System Atrophy for Establishing Disease-modifying Therapies Takayoshi Shimohata 1 1Department of Neurology, Gifu University Graduate School of Medicine Keyword: 多系統萎縮症 , 診断 , αシヌクレイン , 異型症候群 , mimics , multiple system atrophy , diagnosis , α-synuclein , atypical syndrome pp.131-136
Published Date 2020/2/1
DOI https://doi.org/10.11477/mf.1416201492
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More accurate and early diagnoses of neurodegenerative diseases are required to establish disease-modifying therapies. Obtaining a clear diagnosis of multiple system atrophy (MSA), a neurodegenerative disease, can be challenging because MSA has a number of clinical subtypes and many other diseases, known as mimics, are characterized by symptoms that are similar to those of MSA. This paper discusses the factors that make the clinical diagnosis of MSA difficult. Additionally, this paper introduces an attempt at the new clinical diagnostic criteria establishment in accord with recent clinical trials.

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