Exploring Therapeutic Targets for Alzheimer's Disease by Comprehensive Genetic Analysis Takeshi Ikeuchi 1 1Department of Molecular Genetics, Brain Research Institute, Niigata University Keyword: 次世代シークエンサー , レアバリアント , アミロイドカスケード仮説 , 先制医療 , ゲノム医療 , next generation sequencer , rare variant , amyloid cascade hypothesis , preemptive medicine , genome medicine pp.1081-1088
Published Date 2019/10/1
DOI https://doi.org/10.11477/mf.1416201407
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During the past 20 years, genome studies for Alzheimer's disease (AD) have elucidated the pathogenesis of AD including the amyloid hypothesis. However, clinical trials of the disease modifying drugs for AD developed based on the amyloid hypothesis have been largely unsuccessful. New genes associated with AD have been identified through comprehensive genome analyses such as genome-wide association studies and whole genome/exome sequencing using next-generation sequencers. With these efforts, new therapeutic targets to AD have been explored. This review summarizes the genetic make-up of AD in terms of both risk and protective factors from the viewpoint of novel therapeutic targets to AD.

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