BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 71, Issue 8 (August 2019)

What is the Best Initial Treatment for Parkinson's Disease? New Clinical Practice Guideline and My Personal Opinion Atsushi Takeda 1 1National Hospital Organization Sendai-Nishitaga Hospital Keyword: 疾患修飾療法 , 神経保護 , ドパミン補充療法 , L-ドパ回避療法 , 遅延開始研究 , disease modifying therapy , neuroprotection , dopamine replacement therapy , dopamine-sparing therapy , delayed-start study pp.857-867
Published Date 2019/8/1
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Over the last few decades, several delayed-start trials have suggested that early introduction of dopamine replacement therapy can improve the prognosis of Parkinson's disease (PD). Moreover, several observations support that L-dopa is non toxic to normal and diseased substantia nigra in humans. Thus, the clinical practice guideline 2018 for PD recommends L-dopa as an initial treatment for PD, in principle. More recently, several potential disease-modifying therapies have been reported to be effective. Furthermore, several recent studies suggest that exercise can be beneficial in delaying disease progression.

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BRAIN and NERVE-神経研究の進歩
71巻8号 (2019年8月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院