BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 7 (July 2018)

Mild Exercise Results in Robust Brain Activation and Increased Memory Function Hideaki Soya 1,2 , Masahiro Okamoto 1,2 , Yook Jangsoo 1,2 , Hikaru Koizumi 1 1Laboratory of Exercise Biochemistry and Neuroendocrinology, University of Tsukuba 2Sports Neuroscience Division, Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, University of Tsukuba Keyword: 海馬 , 記憶 , 低強度運動 , 海馬神経新生 , hippocampus , memory , mild exercise , adult hippocampal neurogenesis pp.745-752
Published Date 2018/7/1
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Exercise increases adult hippocampal neurogenesis (AHN) and enhances memory function. To elucidate optimal exercise, especially exercise intensity, on hippocampus-based cognition, we established treadmill running animal model, in which running speed was defined using the blood lactate threshold (LT). Using this exercise model, we found for the first time that hippocampal neurons were activated after acute mild exercise (ME) below the LT with running stress minimized. In addition, chronic ME enhanced AHN and spatial memory function. We review the beneficial effects of ME and discuss several molecular factors underlying ME-enhanced hippocampal function.

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BRAIN and NERVE-神経研究の進歩
70巻7号 (2018年7月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院