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Voxel-Based Morphometry in Autism Spectrum Disorder Hidenori Yamasue 1 1Department of Psychiatry, Hamamatsu University School of Medicine Keyword: 発達障害 , 磁気共鳴画像 , 社会行動 , 男女差 , オキシトシン , developmental disorder , magnetic resonance imaging , social behavior , sex difference , oxytocin pp.529-538
Published Date 2017/5/1
DOI https://doi.org/10.11477/mf.1416200779
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Abstract

Autism spectrum disorder shows deficits in social communication and interaction including nonverbal communicative behaviors (e.g., eye contact, gestures, voice prosody, and facial expressions) and restricted and repetitive behaviors as its core symptoms. These core symptoms are emerged as an atypical behavioral development in toddlers with the disorder. Atypical neural development is considered to be a neural underpinning of such behaviorally atypical development. A number of studies using voxel-based morphometry have already been conducted to compare regional brain volumes between individuals with autism spectrum disorder and those with typical development. Furthermore, more than ten papers employing meta-analyses of the comparisons using voxel based morphometry between individuals with autism spectrum disorder and those with typical development have already been published. The current review paper adds some brief discussions about potential factors contributing to the inconsistency observed in the previous findings such as difficulty in controlling the confounding effects of different developmental phases among study participants.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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