Neural Mechanism of Major Depressive Disorder and Bipolar Disorder in Voxel-Based Morphometric Studies Koji Matsuo 1 1Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine Keyword: うつ病 , 双極性障害 , 前部帯状皮質 , 背外側前頭前皮質 , 島領域 , major depressive disorder , bipolar disorder , anterior cingulate cortex , dorsolateral prefrontal cortex , insula pp.519-527
Published Date 2017/5/1
DOI https://doi.org/10.11477/mf.1416200778
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Major depressive disorder and bipolar disorder both possess the characteristic of abnormal mood regulation. Evidence of voxel-based morphometric (VBM) studies has been accumulated, and patients with both disorders show small gray matter volumes in the anterior cingulate, dorsolateral prefrontal cortex, insula, and regions related to emotion regulation. These small gray matter volumes were also shown to be associated with the family history and severity of the disease. Overall, the neural network relevant to mood regulation is thought to be involved in the pathophysiology of both major depressive disorder and bipolar disorder.

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