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The Utility of Voxel-based Morphometry in the Diagnosis of Spinocerebellar Degeneration Nobuyuki Tanaka 1 , Kazunori Nanri 1 , Takeshi Taguchi 1 , Noriko Tanaka 1 , Tsuneo Fujita 2 , Hiroshi Mitoma 3 , Akihiro Kawata 4 , Hidehiro Mizusawa 5 1Department of Neurology, Tokyo Medical University Hachioji Medical Center 2Department of Neurology, Hitachi General Hospital 3Department of Medical Education, Tokyo Medical University 4Department of Neurology, Tokyo Metropolitan Neurological Hospital 5Department of Neurology and Neuroscience, Tokyo Medical and Dental University Keyword: voxel-based morphometry , MRI , 多系統萎縮症 , 脊髄小脳変性症 , 小脳失調 , voxel-based morphometry , magnetic resonance imaging (MRI) , multiple system atrophy , spinocerebellar ataxia (SCA) , cerebellar ataxia pp.699-704
Published Date 2014/6/1
DOI https://doi.org/10.11477/mf.1416101820
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Abstract

We evaluated atrophic sites in the brainstem and cerebellum in the patients with spinocerebellar degeneration by using voxel-based morphometry (VBM). Gray matter atrophy was found extensively in both the cerebellar hemispheres and vermis of subjects presenting the cerebellar variant of multiple system atrophy (MSA-C; n=9). In addition, remarkable white matter atrophy was observed in the middle cerebellar peduncle, brainstem, and cerebellar hemispheres. In contrast, gray matter atrophy was not apparent in the cerebellar hemispheres or vermis of subjects in the SCA3 group (n=6), whereas intense white matter atrophy was visible in the middle cerebellar peduncle, brainstem, and cerebellar hemispheres. White matter atrophy was also observed in the brainstem and surrounding the dentate nucleus in both cases of dentatorubral-pallidoluysian atrophy (DRPLA) (n=2), whereas gray matter atrophy of the cerebellum was not remarkable. In both the SCA6 group (n=3) and the SCA31 group (n=2), gray matter atrophy was prominent in the cerebellar hemispheres and vermis; however, white matter atrophy was not found in the middle cerebellar peduncle and brainstem, whereas symmetric atrophy of white matter was found in the vicinity of the dentate nucleus. In each of these diseases, VBM findings were consistent with the pathological findings; therefore, VBM can be considered a useful tool for the diagnosis of spinocerebellar degeneration.

(Receieved July 24, 2013; Accepted October 25, 2013; Published June 1 2014)


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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