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CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) Shinichi Kan 1 1Department of Radiology, Sagamihara Chuo Hospital Keyword: CLIPPERS , 中枢神経 , MRI , CLIPPERS , central nervous system , MRI pp.1069-1080
Published Date 2016/9/1
DOI https://doi.org/10.11477/mf.1416200554
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Abstract

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) has been recently identified as an inflammatory central nervous system (CNS) disorder.

Punctate and curvilinear gadolinium enhancement (peppering) the pons is a characteristic magnetic resonance imaging (MRI) feature of CLIPPERS. Pathogenesis of this disorder remains unknown. A specific serum or cerebrospinal fluid biomarker for this disorder is currently unknown.

Whether CLIPPERS is an actual new disease or just represents overlapping symptoms from multiple diseases is still debated.

Many differential diagnoses exist even when using imaging as a tool. Pre-lymphoma states, such as grade I LYG (lymphomatoid granulomatosis) and sentinel lesions of primary CNS lymphoma are the most difficult to distinguish.


Copyright © 2016, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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