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Neurotoxicities Associated with CAR-T Cell Therapy Masaki Takao 1 1Department of Clinical Laboratory, National Center of Neurology and Psychiatry (NCNP) National Center Hospital Keyword: キメラ抗原受容体T細胞療法 , CAR-T , 中枢神経 , チサゲンレクルユーセル , アキシカブタジン , chimeric antigen receptor T cell therapy , CAR T cell therapy , central nervous system , tisagenlecleucel , axicabtagene ciloleucel pp.47-58
Published Date 2021/1/1
DOI https://doi.org/10.11477/mf.1416201711
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Abstract

Chimeric antigen receptor (CAR) T cell therapy has recently approved for CD-19-positive B-cell malignancies, such as acute lymphoblastic leukemia and diffuse large B-cell lymphoma in Japan. CAR-T therapy may develop cytokine release syndoromes as well as central nervous system complications (CRES/ICANS), including encephalopathy, consciousness distrubence, apahsia, seizure, motor weakness, and cerebral edema. Although the pathomechanism of CRES/ICANS remains unsolved, an appropriate intervention is important for patients. In addition, several chemotherapeutic agenets used before CAR-T cell therapy may also lead to the development of central nervous system disorders. Therefore, neurologists must be familiar with the complications of newly developed chemotherapies.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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