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IDH1/2 Mutations in Gliomas Sumihito Nobusawa 1 , Hideaki Yokoo 1 1Department of Human Pathology,Gunma University Graduate School of Medicine Keyword: IDH1/2 mutation , glioma , glioblastoma , brain tumor pp.1378-1386
Published Date 2011/12/1
DOI https://doi.org/10.11477/mf.1416101083
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Abstract

 The NADP+-dependent isocitrate dehydrogenases 1 and 2 (IDH1/2) catalyze the oxidative decarboxylation of isocitrate into α-ketoglutarate (α-KG). IDH1 and IDH2 mutations have been frequently found in some types of gliomas (low-grade diffuse gliomas WHO grade Ⅱ, anaplastic gliomas WHO grade Ⅲ, and secondary glioblastomas WHO grade Ⅳ), and have received significant attention because of their specificity to single codons. Since the unveiling of IDH1/2 mutations, many studies have investigated their clinical impact on gliomas. While the favorable influence of these mutations in high-grade gliomas has been well established, their prognostic impact on low-grade diffuse gliomas is much less clear. While the mechanism of IDH1/2 mutations in gliomagenesis remains to be clarified, its elucidation might lead to novel therapeutic strategies against gliomas.

(Received: July 25,2011,Accepted: September 12,2011)


Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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