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Slowly Progressive Anarthria and Disturbed Voluntary Respiration―A Case Report Eiyai Lee 1 , Toshiki Uchihara 2,3 , Akira Machida 2 , Sadakiyo Watabiki 2 1Department of Speech,Language and Hearing Disoder,Clinical Welfare College 2Department of Neurology,Musashino Red Cross Hospital 3Department of Neuropathology,Tokyo Metropolitan Institute for Neuroscience Keyword: progressive anarthria , progressive loss of speech , voluntary respiration , dysphonia pp.629-632
Published Date 2007/6/1
DOI https://doi.org/10.11477/mf.1416100086
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Abstract

 A 68 year-old right-handed male initially felt an abnormal sensation in the throat and slight difficulties in phonation and articulation. The difficulties slowly progressed. Dementia and kinetic disorder of limbs has not been observed over two years after onset. Although bilateral cortico-bulbar tract sign such as pathological laughter was noted. His articulatory movements were small and indistinct. Phonation was slightly explosive and breathy as if panting out. His clinical feature could be differentiated from primary progressive aphasia because he was not aphasic with excellent word finding,and fell into the realm of progressive anarthria. On SPECT,hypoperfusion was seen in the left frontal region,the left parieto-temporal region,and the right frontal region to a lesser extent.

 A peculiarity of the patient was in that he had accompanied a difficulty in voluntary inspiration such as taking a deep breath. Because fiberoptic examination of the larynx demonstrated that the vocal cords opened normally when he tried to take a deep breath,the difficulty in inspiration was best explained by loss of voluntary control over diaphragmatic contractions. On voluntary expiration,sustained blowing through the pursued lips (soft blowing) was not successful either. On the other hand,blowing out several candles one by one or blowing up a balloon (hard blowing) was successful. In soft blowing,a voluntary and meticulous control of the diaphragm is necessary to counteract the spontaneous recoil of the lungs. In hard blowing,expiratory muscles may contract forcefully without participation of the diaphragm. This discrepancy is again explained by loss of voluntary control over the diaphragmatic movements. This deficit could have affected phonation; maintaining an adequate vibration on the vocal cords for a certain period of time,it is necessary to control the subglotal pressure at an appropriate level by diaphragmatic control. We believe this is the first patient with a progressive anarthria in which defective voluntary respiration possibly caused impairment of phonation.


Copyright © 2007, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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