Japanese
English
- 有料閲覧
- Abstract 文献概要
- 1ページ目 Look Inside
当院泌尿器科に入院した患者を対象として,抗生物質関連大腸炎(下痢症)の発症頻度,下痢便中の細菌(特にClostridium difficile)との関連,下痢発症例の患者背景,治療等について検討した。何らかの形で抗生剤の投与を受けた入院患者407例中52例(12.8%)に64件の抗生剤投与が原因と考えられる下痢が発症した。64件のうち23件(35.9%)の下痢便にClostridium difficileが陽性であった。下痢発症例では高齢者,悪性腫瘍患者に多い傾向があった。一方,下痢のない症例では197例中14例(7.2%)で便中Clostridiumdifficileが陽性であった。Clostridium difficileはMetronidazole,Vancomycin等に高い感受性をもち,これらの投与によく反応した。
Recently, Clostridium difficile and its toxins have been identified as the causative agents in the majority of antibiotics associated colitis, which is featured by diarrhea following antibiotic therapy. We studied the incidence of antibiotics associated colitis in 407 cases, admitted to our department. And we also studied fecal specimens from a total of 194 cases without diarrehea, with or without antibiotic therapy. The results were as follows : 1) Of 407 cases with antibiotic therapy, diarrhea was observed in 52 cases (12. 8%).
Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.