原発性膀胱上皮内癌の病理学的検討

PRIMARY CARCINOMA IN SITU OF THE URINARY BLADDER: A PATHOLOGICAL STUDY

　原発性膀胱上皮内癌と診断して膀胱全摘出術を行つた12例の病理学的検索を行つた。膀胱上皮内に癌がとどまるものは3例のみで，残りは粘膜固有層から筋層にいたる微小浸潤，または深部浸潤を伴つていた。隣接尿路に上皮内癌が合併する症例の比率は，尿管下端50％，尿道33％，前立腺導管20％であつた。尿管カテーテル尿細胞診の陽性例は，すべて尿管下端に上皮内癌を併発していた。以上の結果から，原発性膀胱上皮内癌に対しては尿管下，端尿道，前立腺を含む膀胱全摘出術を早期に行うことが適切な治療法と思われる。

Twelve paticnts diagnosed preoperatively as having in situ of the bladder tumor underwent total cystourethrectomy. The excised specimens were studied pathologically. In three patients ncoplasms was limited to the mucosa, while in nine patients neoplasms had invaded into the submucosal or muscular layer. Carcinoma was simultaneously found in the lower ureter, urethra and prostatic ducts in 50%, 33% and 20% of the patients respectively. Positive cytology of the urine obtained by ureteral catheterization