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OCCURRENCE OF THE SO-CALLED LANGERHANS GRANULES IN THE SKIN LESIONS OF LETTERER-SIWE DISEASE: AN ELECTRON MICROSCOPIC OBSERVATION Mitsumasa ITOH 1,2 1Department of Anatomy , School of Medicine, Chiba University 2Department of Dermatology, School of Medicine, Chiba University pp.153-161
Published Date 1969/2/1
DOI https://doi.org/10.11477/mf.1412200464
  • Abstract
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Langerhans granules, which had been regarded as specific for Langerhans cell of the normal epidermis, were found in the pathologic histiocyte of Letterer-Siwe's disease.

This disease should belong to histiocytosis X as well as eosinophilic granuloma and Hand-Schüller-Christian's disease. They might be different expression of the same entity.

As for the origin of Langerhans cell there is a possibility of histiocyte theory, as well as melanocyte theory or peripheral nerve theory.

There are two theories of origin of Langerhans granule-) A theory that it is produced at the Golgi apparatus and excreted or (2) A theory that it is formed at the cell membrane and phagocytized into the cytoplasm. It could not be concluded from this study that which theory might be more probable.


Copyright © 1969, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1324 印刷版ISSN 0021-4973 医学書院

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