下腿の炎症性硬結における血管変化について

HISTOPATHOLOGIC STUDIES ON NODULAR INFLAMMATORY LESIONS OF THE LEGS, ESPECIALLY ON VASCULAR CHANGES

I．はじめに

　結節性紅斑，硬結性紅斑を血管変化の立場に立つて，病理組織学的に再検討し，この検索資料を基礎にして，臨床的にこれら両者の中間型の鑑別を試みた。またこれら疾患にみられる如き血管炎を実験動物に再現し，この実験を通して，血管炎の発生，ひいてはこれら疾患の発症病理の解明を企てた。これらの研究，特に後者の実験的研究はいまだ極めて不十分であり，報告するに未だしの感があるが，今後の研究を進めて行く上の整理をかねて，敢えて発表する次第で，この点御寛恕ならびに御批判をいただければまことに幸いである。

Venous system was mainly affected in the vascular changes of erythema nodosum and erythe-ma induratum. One of the characteristic manifestations of erythema induratum was capillary endothelial proliferation besides the known characteristics of this disease.

So-called intermediate type between erythema nodosum and erythema induratum was mainly erythema induratum. Main histologic picture in some of the intermediate form was thrombo-phlebitis, and the author suggested that this form might be called vasculitis nodularis, differing from nodular vasculitis (Montgomery). Experimental production of the vascular Arthus reaction suggested a possibility of existence of an allergic process in the vasculitis, while there might exist a possibility of a nonspecific inflammatory process of the Schwartzman type.