頭頸部癌に対する少量CDDP・放射線同時併用療法の検討

Combination Therapy Using Radiation and Daily Low Dose of Cisplatin for Head and Neck Cancer

　はじめに

　頭頸部癌の放射線治療効果を増強させる目的で，従来よりシスプラチン，5-FU，ブレオマイシンなどの同時併用が行われてきたが，最近では少量シスプラチンと放射線同時併用療法が注目されて，その安全性と有効性が報告されている^1〜7）。今回，われわれが行った少量シスプラチンと放射線同時併用療法の治療効果と副作用の発現状況について検討した。

27 patients with head and neck cancer were treat-ed with combination therapy using radiation and a daily low dose of cisplatin (5 mg/body or 5 mg/m²). As a result, total response rate was 91%. Incidence of the acute complication of leukopenia more severe than grade 2 was 63%. Leukopenia was the most critical side effect and it was seen even after the completion of cisplatin administration in most patients. Severe renal dysfunction was not seen.