Reye症候群の1症例の側頭骨病理所見

Temporal Bone Pathology of the Reye Syndrome

　はじめに

　Reye症候群は，1963年にオーストラリアのReyeら^1）によって報告された小児の急性脳症と肝障害を生じる原因不明の疾患である。しかも症状の経過も急激であり，高率に死に至る重症な疾患である^2）。病理学的変化は脳浮腫や肝臓の脂肪変性が特徴とされ，出血傾向を伴うことも多い^3,4）。

　しかし側頭骨病理に関する報告は，これまでRaulら^5）の1例しかなく，Reye症候群の側頭骨病理変化の詳細は不明な点が多い。今回われわれは，Reye症候群症例の側頭骨病理を観察する機会を得たので，Raulら^5）の症例との比較も含め報告する。

Reye syndrome is an idiopathic childhood disease reported by Reye et al. in 1963. This disease causes acute encephalopathy, following a rapid and fatal course in most cases. We report temporal bone pathology of a patient with Reye syndrome. In the literature, only one case report of temporal bone pathology of this syndrome was described. Themain pathological findings of the temporal bone included blood flow congestion in the blood vessels of the inner ear and hemorrhage in the internal acoustic meatus. There was no degenerative changes in the sensory organ or nerves of the inner ear. Vascular congestion in the inner ear appeared to be caused by cerebral circulatory disorder related to acute encephalopathy. Hemorrhage in the inter-nal meatus appeared to be associated with sub-arachnoid hemorrhage. There was no secondary nervous degeneration. These findings may be caus-ed by a short duration of brain death and a short time lapse between death and autopsy.