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Blood Transfusion associated GVHD, diagnosed by DNA Analysis: Report of a Case Ken Shimizu 1 1Department of Otorhinolaryngology, Musashino Red Cross Hospital pp.489-494
Published Date 1993/6/20
DOI https://doi.org/10.11477/mf.1411900738
  • Abstract
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A 62-year-old male with carcinoma of the hy-popharynx developed a blood transfusion asso-ciated graft-versus-host disease (TA-GVHD). The patient presented with fever and skin rash 14 days after laryngo-pharyngo-esophagectomy, follwed by liver dysfunction, diarrhea, pancytopenia, bone marrow aplasia, and disturbance of consciousness. The diagnosis of TA-GVHD was made by DNAsequence polymorphism analysis. The results de-monstrated the replacement of patient DNA types with donor types at the time of GVHD.

For preventing TA-GVHD, irradiation in a dose of 15~50 Gy to blood products before transfusion was recommended.


Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1316 印刷版ISSN 0914-3491 医学書院

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