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Three Cases with Disequilibrium caused by Carmofur, a 5-FU Derivative Toshihisa Murofushi 1 1Department of Otolaryngology, Tokyo Metropolitan Fuchu Hospital pp.359-363
Published Date 1989/5/20
DOI https://doi.org/10.11477/mf.1411200343
  • Abstract
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The authors presented three cases with disequi-librium caused by carmofur, a 5-FU derivative. Patients were a 47-year-old male suffered from colonic cancer with liver metastases, a 67-year-old male with colonic cancer and a 82-year-old male with nasopharyngeal cancer.

Neurotological findings-direction changing apo-geotropic positional nystagmus, downward-beating positioning nystagmus, saccadic pursuit, ocular dysmetria and loss of visual suppression-suggested that disequilibrium in these cases might be caused mainly by cerebellar lesions.

In addition, the first patient showed extra-pyramidal signs and disturbance of consciousness and the second patient manifested mental change. These signs and symptoms suggested that there also existed supra-tentorial lesions.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1316 印刷版ISSN 0914-3491 医学書院

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